Naltrexone

Is an opioid antagonist and works by blocking opioid receptors so that they do not become activated.
  • Prevents opioids from producing effects
  • You will not feel the effects of opioids or feel high
  • It can also reduce cravings for opioids. There is an oral form and a long-acting injectable formulation, known by the brand name Vivitrol. Only the long acting injectable is FDA approved for OUD.
  • If you want more information on Vivitrol, check below
  • Naltrexone can lead to reduced tolerance of opioids. Therefore, taking the same amount or even lower doses of opioids can put you at a higher risk of overdosing

FAQ’s

Check frequently asked questions:

1 When can I start taking naltrexone? You have to be completely off opioids for 7-10 days before taking naltrexone.
2 Can I overdose on it? You will not overdose from naltrexone. However, it has not been shown to reduce the risk of overdose and death. If you miss an injection dose, your risk of overdose can increase greatly if you decide to use opioids.
3 How does it work? Naltrexone blocks the euphoric and sedative effects of opioids. It does this by binding to and blocking opioid receptors, which also helps reduce opioid cravings.
4 Naltrexone is the best option for MOUD. There is no one best choice. It is all up to you and your treatment goals. However, there is much more evidence of the effectiveness of methadone and buprenorphine in reducing mortality associated with OUD.